The Bloom #148 Free Edition rolling

Over the last week, it seems that psychedelic research is coming at us faster than ever before.

Researchers re-analysed data from a single-blind study of psilocybin-assisted therapy for depression and found that psychological flexibility, mindfulness, and living according to one’s values improved, even four months after the study's conclusion.

Next to academic research, I'm seeing an uptick in publications from the psychedelic drug developers, including a new publication from Beckley Psytech that shows the safety of their nasal 5-MeO-DMT formulation.

Finally, I want to highlight a study from late March that just crossed my radar. It's a real-world study, but unfortunately, not in a clinical setting. The study looked at the effect of MDMA during the October 7 attack. It found a protective effect leading to reduced mental distress and PTSD symptom severity.

Floris - Founder of Blossom

ps ICPR, added a policy-focused day (Pathways to Access Summit) at the start of the conference; with the code BLOSSOM50, you can get a €50 discount.

Latest Psychedelic Research

1 Psychedelics and the 'inner healer': Myth or mechanism?​

This re-analysis of a single-blind, placebo-controlled study (n=19) of psilocybin (21mg/70kg) in combination with therapy (ACT, 8x) finds that psychological flexibility, mindfulness, and living according to one’s values improved after psilocybin and stayed better through the 16-week study period. It also shows that greater psychological flexibility and experiential acceptance were linked with lower depression scores after psilocybin.

2 Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-methoxy-N,N-dimethyltryptamine benzoate) in healthy participants​

This double-blind, placebo-controlled study (n=44) examines the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of BPL-003, a novel intranasal benzoate salt formulation of 5-MeO-DMT (up to 12mg), in healthy participants. BPL-003 was well tolerated, showing rapid absorption and elimination.

3 Trauma Under Psychedelics: MDMA Shows Protective Effects During the Peritraumatic Period​

This retrospective cohort study (n=657) examines the acute experiences and peritraumatic processing of survivors from a high-casualty terror attack, with approximately two-thirds under the influence of psychoactive substances. Those who experienced the trauma under MDMA showed improved intermediate outcomes, including increased social support, more interactions, and better sleep quality, leading to reduced mental distress and PTSD symptom severity. These findings suggest a potential protective effect of MDMA during trauma.

More new research

• ​A dual-receptor model of serotonergic psychedelics: therapeutic insights from simulated cortical dynamics​
• ​Methyl transfer in psilocybin biosynthesis​

ps More articles are in the pipeline and will be shared on our Twitter​

New on Blossom

1 Getting The Ducks in a Row in Europe – The EMA Workshop on Psychedelics – Day 1​

Europe explores the future of Psychedelic Medicine in a workshop led by the European Medicines Agency (EMA) - First Day

(recap of the second day and a fuller analysis will folllow - for now, please check out the excellent analysis by Josh Hardman from Psychedelic Alpha)

2 Psychedelic Research Links 2024​

All the other papers that have come out this year that don't have a separate entry in the database.

Spotlight

1 ICPR (Event)

In just 50 days, the sixth edition of the Interdisciplinary Conference on Psychedelic Research (ICPR 2024) will take place. It is organized by the OPEN Foundation. It is an academic conference focused on high-quality scientific and scholarly research into psychedelics.

The main conference takes place from June 6 to 8. This is a must-go-to conference for those involved with the academic side of psychedelics.

Join ICPR 2024 with a €100 discount using the code BLOSSOM100

Join the pre-conference day (June 5th) on policy & implementation (PATHS) with a €50 discount using the code BLOSSOM50

Molenvaart 76, Anna Paulowna, NH 1761AL
​Unsubscribe · Preferences​