The Bloom #140 Free Edition let's get creative

Research has been a bit slower in the last week(s), but that has given me more time to present a few updates on Blossom to you.

Starting with 10+ new events being added to the Events database. Find all (big) psychedelic conferences in one place. Ranging from online conferences (e.g. Psychedelics Design, where I will be speaking & moderating) to international scientific gatherings (e.g. ICPR and Horizons).

I've also started updating the overview pages, starting with the Smoking page (which, alas, hasn't needed much updating for such a pivotal topic).

Please let me know in a reply if you're especially interested in seeing a topic page updated or created.

Floris - Founder of Blossom

ps I'm excited to invite you to the Psychedelics Design Conference on April 11, 2024. Psychedelics Design and Blossom created a half-day Online Conference featuring well-known experts such as Paul Austin, Michel Rojkind, Jemma Campbell, and yours truly. Join us to explore the cultural nuances that shape our creative and psychedelic landscapes. Tickets are priced at £20 / $25 and available here. Use code Floris15 for a 15% discount.

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Latest Psychedelic Research

1 The antidepressant effects of vaporized N,N-Dimethyltryptamine: a preliminary report in treatment-resistant depression​

This open-label Phase IIa clinical trial (n=6) examines the efficacy of vaporized DMT in treating treatment-resistant depression (TRD). Patients experienced significant reductions in two depression scores (MADRS & PHQ-9), with 83% responding to treatment by day 7 and 66.67% achieving remission. The rapid onset and sustained antidepressant effects of vaporized DMT suggest its potential as a practical and accessible option in psychedelic treatments for depression within interventional psychiatry.

Related: Safety and tolerability of inhaled N,N-Dimethyltryptamine (BMND01 candidate): A phase I clinical trial​

2 Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins​

This review (2023) assesses the potential long-term impact of microdosing psychedelics on cardiac health, particularly focusing on LSD and psilocybin. Despite the increasing popularity of microdosing, concerns arise due to structural similarities between these substances and medications associated with cardiac fibrosis and valvulopathy. The review emphasizes the need for future studies to evaluate the safety of prolonged microdosing and discusses the relationship between drug-induced cardiac fibrosis and the 5-HT2B receptor.

3 Coming back together: A qualitative survey study of coping and support strategies used by people to cope with extended difficulties after the use of psychedelic drugs​

This qualitative study (n=608) investigated coping strategies employed by individuals experiencing difficulties persisting for at least one day after a psychedelic experience. Predominant individual coping strategies included meditation and prayer, along with self-educational activities like reading and journaling. Social coping methods were commonly seeking support from friends or family, and obtaining assistance from a therapist or coach, with reported benefits including feeling heard, accepted, and sharing similar experiences.

More new research

• ​So how special is special K? A systematic review and meta-analysis of ketamine for PTSD RCTs​

New on Blossom

1 Blossom Pro: Research Briefing #4 – Microdosing Risks, Managing Challenging Experiences, and DMT for TRD​

The risks of microdosing, challenging experience of psychedelics, and the promise of short-lasting DMT for TRD.

2 Ps​ychedelics & Smoking (Updated)

Smoking is a serious public health threat. Thankfully, psychedelics are promising to help people kick the habit for good.

3 Psychedelic Research Links 2024​

All the other papers that have come out this year that don't have a separate entry in the database.

Spotlight

1 Psychedelics Design Conference (Event)

I'm excited to invite you to the ​Psychedelics Design Conference​ on April 11, 2024. Psychedelics Design and Blossom created a half-day Online Conference featuring well-known experts such as Paul Austin, Michel Rojkind, Jemma Campbell, and yours truly. Join us to explore the cultural nuances that shape our creative and psychedelic landscapes. Tickets are priced at £20 / $25 and ​available here​. Use code Floris15 for a 15% discount.

2 MDMA/psychedelics in romantic relationships (Study)

Are you planning to take MDMA, a psychedelic drug/attend a psychedelic retreat with your romantic partner and want to help psychedelic research?

Imperial College London is now investigating the long-term effects of taking psychedelics, MDMA, ketamine, 2C-B, etc. in romantic couples, from intimacy to attachment styles and sexual satisfaction. Click here to know more and sign up:

​https://survey.alchemer.eu/s3/90617328/Psychedelics-and-Couples-Sign-up​

This study is for people in a romantic relationship, however you can also participate by yourself if your partner do not want to participate. One couple member must enrol in the study first before receiving a unique link to share the study with their partner. You will be asked to select the date of your experience, and you will receive questionnaires at 5 different time points.

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